In his review, he called the musical “a muddled and momentum-less retooling of the familiar fairy tale in search of a coherent point of view as if it were a glass-slippered foot. Webber wrote the music and David Zippel penned the lyrics.Ĭritics were not kind to “Bad Cinderella,” with Variety‘s Naveen Kumar saying the show lived up to its name… literally. From Joseph and the Amazing Technicolor Dreamcoat (1969) to Cinderella (2021), his work has been consistently seen on world stages. Andrew Lloyd Webber has composed the scores of some of the world’s most famous musicals. Emerald Fennell, the Oscar-winning screenwriter of “Promising Young Woman,” wrote the original story and book, which was adapted by Alexis Scheer. Bad Cinderella (Lloyd Webber) Full-Length Musical, Comedy / 6f, 2m. The show, about an outcast who eventually realizes appearances aren’t everything and develops a new take on the concept of “happily ever after,” closed the following June before transferring to Broadway this March. His storied four-decade run started with “Evita” in 1979 and continued with “Cats” “Starlight Express,” “Sunset Boulevard” and, most recently, “School of Rock.” He’s composed 13 productions over the last four decades, including 1970’s “Jesus Christ Superstar” and 1968’s “Joseph and the Amazing Technicolor Dreamcoat.”Ī feminist retelling, of sorts, of the classic fairy tale, “Bad Cinderella” opened on London’s West End in the summer of 2021 after several pandemic-related stops and starts. Andrew Lloyd Webber has decided to shut down Cinderella, his latest musical, until February at the earliest, blaming 'this wretched virus' for putting paid to 'the joy of entertaining audiences'. I discovered Andrew Lloyd Webber as a preteen and Ive. With the shuttering of “Bad Cinderella” and “Phantom of the Opera,” which was the longest-running production in history before the famous chandelier fell one last time in April, Webber has broken his 43-year streak of shows on Broadway. Protests outside London's Gillian Lynne Theatre at Andrew Lloyd Webber's decision to move the show to Broadway. Cinderella September-through-November: Andrew Lloyd Webbers Cinderella (2021 stage musical).
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Results from the primary analysis of CheckMate -274 were presented in an oral presentation during the American Society of Clinical Oncology Genitourinary Cancers Symposium in February 2021. Opdivo was generally well tolerated, with a safety profile that was consistent with previously reported Opdivo studies in patients with solid tumors. placebo, regardless of patients’ PD-L1 expression levels. In the trial, Opdivo demonstrated a statistically significant and clinically meaningful increase in disease-free survival (DFS) vs. The filing was based on results from the pivotal CheckMate -274 trial, the first positive Phase 3 trial of an immunotherapy in this setting. We look forward to working with the FDA towards the goal of bringing the first adjuvant immunotherapy option to these patients in the U.S.” “Based on the ground-breaking disease-free survival results from CheckMate -274, we believe Opdivo has the potential to change the future of treatment for muscle-invasive urothelial carcinoma. “After patients undergo surgery for muscle-invasive urothelial carcinoma, they continue to face uncertainties given the high rate of disease recurrence and the lack of safe and effective treatment options,” said Dana Walker, M.D., M.S.C.E., vice president, development program lead, genitourinary cancers, Bristol Myers Squibb. The FDA granted the application Priority Review and assigned a Prescription Drug User Fee Act (PDUFA) goal date of September 3, 2021. Food and Drug Administration (FDA) has accepted the supplemental Biologics License Application (sBLA) for Opdivo (nivolumab) for the adjuvant treatment of patients with surgically resected, high-risk muscle-invasive urothelial carcinoma, based on results from the CheckMate -274 trial. PRINCETON, N.J.-(BUSINESS WIRE)- Bristol Myers Squibb (NYSE: BMY) today announced that the U.S. Food and Drug Administration assigned a target action date of Septemif approved, Opdivo would be the first adjuvant immunotherapy option for patients with muscle-invasive urothelial carcinoma in the U.S.ĬheckMate -274 is one of four positive Phase 3 trials for Opdivo -based treatments in earlier stages of cancers Application based on Phase 3 CheckMate -274 trial, in which Opdivo nearly doubled disease-free survival compared to placebo Had breakfast twice at the French restaurant for preferred guests. Liked the sports lounge area with gigantic TV and fast waitresses. Bartenders in the preferred lounge were very friendly and made great drinks. Bartender made great drinks and waiters were always hustling to get drinks and food out to guests. Stayed mostly at the Preferred pool where it was quiet and infinity pool overlooking ocean. We had a one bedroom suite with a separate livingroom area. Enjoyed the ocean sounds from our balcony. Stayed in the Preferred Ocean Front room. Preferred suites have a larger than typical sitting areas and some have Jacuzzi tubs on the balcony. All rooms come with flat-screen televisions, bathrobes, daily restocked mini-bars and Jacuzzi tubs. The latter configuration, while pretty, offers less privacy to parents. Other units have the sitting area a step down from the beds. Select units feature separate sitting areas adjacent to semi-private sleeping areas. The accommodations are spacious and tastefully decorated with a mix of rattan chairs or benches and dark wood slatted headboards with turquoise fabric accents. On a Caribbean getaway, we like to see a panorama of blue sky, blue water and white-sand beach - more than is visible in one glance at Now Jade. Combined with the prevalence of connecting bridges, the property conjures more of an urban than an island feel. Rows of multi-story guest buildings line the pool areas and stretch along the sides of the property. Of course, everyone is welcome.Īccommodations at Now Jade are in nine buildings throughout the property. How to differentiate between the Dreams and the Now properties since both are large all-inclusive resorts in the Riviera Maya? The answer is still open-ended, but it feels as if Now Resorts aim for a more fashionable experience, attempting to appeal to vacationers in their 20’s, 30’s and 40’s - with or without children - more than to other groups. In the Caribbean AMR’s other brands include Dreams Resorts - positioned for couples, singles and families. Now Jade and Now Sapphire, another AMResorts’ Riviera Maya property, are beachfront, all-inclusive properties - the first Now properties in the company’s chain. It’s a small thing, but it is nice not to wear one. Interestingly, wrist bands are not de rigeur. Depending on the time of day, the staff invites those waiting in a long line at check-in to enjoy the buffet and then come back later when the line has thinned. When a busload or big tour group pulls in, then the line can move slowly. Non-preferred guests line-up at the lobby registration desk. Preferred guests have a separate room for check-in. A staff member welcomes guests with cold face cloths, sparkling wine and juice or water for children.Īt this large all-inclusive resort of about 550 rooms, there are two categories of guests. The reception area is a swirl of blue and green hues from the carpeting to the turquoise chairs. 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The Marketing Ecosystem Blueprint explores this in the form of a comprehensive report, combining interviews with marketing leaders from BT, TSB, Molson Coors and Nomad Foods with a landmark study of over 100 CMOs, to paint a picture of how brands are thinking about and approaching their marketing ecosystems. What should a modern marketing ecosystem look like is there a blueprint to set brands up for success? In an age of continuous disruption where businesses must innovate fast, marketing operations are more important to organisational success than ever before. The dashboards eliminated the time needed to put together on-demand reports while providing managers with full visibility of team performance.What is the Marketing Ecosystem Blueprint? Such an opportunity automatically appears on the Quote Board to provide visibility on the type of quote required, the person working on quote generation, and the timeframe for completion. When the opportunity moves to a particular stage, the sales rep requests a quote. The dashboards help the team identify what they need to improve to reach the target.Īdditionally, one of the dashboards was created to visualize the quote management process. Customized dashboards have been developed to provide an instant overview of the sales team’s daily progress and marketing campaign results. Thanks to the mobile application, sales reps can promptly add new contacts to Creatio, and the system will remind them to take the next steps in the sales process.ĭata efficiency was one of the key project goals, as such, Techosystem ensured the BPA team could download the required analytics and act on them. Labor-saving automation saved extra time for the reps to spend in the field attracting prospective customers. The centralized solution significantly contributed to the marketing and sales alignment bringing on a successful lead hand-off process.īPA sales reps often present their solutions at industry trade shows. Automated sales workflows outlined each step for sales reps as they progressed through the sales funnel, starting from the lead assignment, ultimately leading to opportunity conversion. A holistic customer view enabled intelligent audience segmentation for personalized marketing campaigns resulting in streamlined lead generation. Now customer data and every interaction are logged in the system and easy to track. The system works exactly the way we want it to work,” says Scott Williams, Regional Sales Manager at BPA.Ĭreatio platform has become a digital hub for BPA sales and marketing teams. “It was impressive to see how quickly we could adopt the system and implement the desired workflows. Platform flexibility allowed BPA employees to start configuring the processes and building dashboards independently shortly after the implementation. The system was implemented with the help of Creatio’s partner Techosystem, who ensured a smooth transition and quick adaptation of the BPA team to the new work environment. Bill Hicks, and many others.Lo Wang catches up with his former boss but the meeting doesn't end up the way he thought. Texts from these commonly refer to developers, proverbs, Star Wars, Highlander, Matrix, Mario games, Bioshock, web browser, polish comics, and quotes from XVII century poetry, Woody Allen, Ashleigh Brilliant, George Carlin. Dave Bowman (the protagonist) and common quote from the move. The red lens looks very familiar and the label on the scanner reads "Harô Dave" (jap. In Chapter 12, after a rough tram ride/Half-Life reference, Lo comes across a terminal with retinal scanner. A direct reference to this scene from Terminator 2.ĭuring intro Lo sings, after the radio, the main theme for the movie "The touch" by Stan Bush. At the nearest end of the canal lies, in flames, truck wreck with a burning tire rolling away from it. In Chapter 3 while shaving his head Lo makes a direct reference to Travis Bickle.ĭuring Chapter 3 after witnessing a police car crashing into the van Lo descends into the canal. The Easter egg itself is near exact copy of the same Easter egg in Shadow Warrior Classic. This is a reference to identical scene in Monty Python and the Holy Grail. In Chapter 14 a secret area can be found in which a Demon Rabbit sits with a crusaders helmet and a golden chalice at either side. The Easter egg itself is the exact copy of the same Easter egg in Shadow Warrior Classic. This is a reference to a martial arts movie actor named Jackie Chan. Above the coffin there's a plate with following words: "Chan. In Chapter 16 a room with a coffin can be found. The torso also has similarities to the main character from Ninja Gaiden series. This torso is the same one used in early Shadow Warrior Classic build, that was ultimately cut from the official release. Behind, a hanging retro torso of a ninja can be seen. In Chapter 2 crossing the river bed, at the end of it is a grate. Their products are designed for gaming and can be identified by their alien-themed designs. This is a reference to Alienware, American computer hardware subsidiary of Dell, Inc. Through out Shadow Warrior (2013) cargo containers with word Alienware written on them, can be found. After finding them, Lo Wang will comment on their pixel art design. Through out the Shadow Warrior (2013), secret "retro" rooms can be found, that are entire segments from levels in Shadow Warrior Classic. Retro Rooms " Pixel art huh? How avant garde." -Lo Wang after seeing the retro room. The girls can't be interacted in any way. Lo Wang will comment that he wish they were in HD, referencing to their 1997 graphic look. The Easter egg can be found in Shadow Warrior Classic too.Ĭlassic Girls " I wish you were in HD." - Lo Wang after seeing the classic girls.Īll over Shadow Warrior (2013) in secret rooms, girls from Shadow Warrior Classic can be found in the game. This is a jab to Japanese car maker Mitsubishi. In Shadow Warrior (2013) most cars have "Titsubishi" written on the back of them. In Chapter 2 when crossing the rooftops, if you look at the mountain side, Godzilla from popular movie series of the same name, can be seen walking through the mountainside, until it disappears behind the mountain. In the beginning, Godzilla can also be seen in the background of the cutscene after you take out a cigarette. "This type of missile, nicknamed 'Nuke Dukem', contains more powerful explosives, increasing explosion radius by 30%" Half-Life Ī "joyous ride" with the underground tram at the beginning of Chapter 12 is a direct reference to notorious playable intro from the game Half-Life. Shadow Warrior machine allows listening the unique "Lo Wang's rap" song.ĭescription on Heavy Warheads Upgrade for Yari Type-24 Rocket Launcher says One can "insert a coin" into any arcade machine met in game to listen to few music track from their soundtracks. The robot from the game also can be found as an Easter egg in the arcade and at the of first Chapter, when looking through a fake level end curtain. Reference to Flying Wild Hog earlier game Hard Reset can be found through out the game. Besides putting money in the arcade, they can't be interacted in any way. References to original Shadow Warrior Classic can be found through out the game, in the from of posters and arcades. When picking up Tosainu Type 13 Revolver, Lo Wang will say this line: " What's that? You want me to take this? Well I guess it's dangerous to go alone." This is a reference Zelda video game series. What is Brian Knepper's email address?īrian Knepper's email address is We have 2 additional emails on file for Brian Is Brian Knepper married? How old is Brian Knepper?īrian Knepper's is 31 years old. What is Brian Knepper's phone number?īrian Knepper's phone number is (717) 263-1011. Carr to William Roller Grattan, 3235 Pleasant Valley Road Ashby District, $250,000.6141 Occoquan Forest Dr, Manassas, VA 20112Ĥ755 Planters Ridge Dr, Tallahassee, FL 32311ġ657 Paul Russell Rd, Tallahassee, FL 32301ģ12 Deckbar Ave #107, Jefferson, LA 70121ģ52 Dreshertown Rd, Fort Washington, PA 19034įAQ: Learn more about our top result for Brian Knepper What is Brian Knepper's address?īrian Knepper's address is 3934 Rectortown Rd, Marshall, VA 20115. Nalbach, 310 North River Road Ashby District, $287,000. Douglas, 179 Edom Lane Plains District, $226,500. to David Metz and Yvonne Metz, lot 132 phase 1B/1C section 7 of Shady Creek, $323,475. Painter, lots 6 7 and 8 in block 85 on west side of Fourth Avenue Stonewall District, $192,000.
The venue’s eclectic ambience can be enhanced to reflect your desired aesthetic, resulting in an event that’s 100% you. You and your loved ones are sure to enjoy the cozy couches and vibrant rugs, which offer a home-like atmosphere. Host anywhere between 10 to 80 guests here as you anticipate your bundle of joy. Located in the heart of North Hollywood’s Art District, Bexx Secret Garden is ideal for mothers looking for a secluded retreat in the center of Los Angeles. Dishes such as thoughtfully crafted pasta and grilled seafood bring the robust flavors of Europe to Los Angeles’ Silver Lake neighborhood. While here, you and up to 75 loved ones can enjoy Chef Zach’s contemporary Italian cuisine. The venue’s organic tones and textures will not only look great on the day, but they’ll also make for beautiful backgrounds for timeless photos. Floor-to-ceiling windows, modern furnishings, and polished concrete floors fill the space, creating a familiar yet chic ambience in Los Angeles, CA. 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No matter the size of your party, this setting is sure to delight and dazzle. The eye-catching venue can accommodate up to 250 guests for memorable gatherings. The restaurant even includes a courtyard so that you can enjoy alfresco culinary experiences. Rustic chandeliers and exposed wood beams add to the interior’s captivating ambience.ĭine on coastal Californian cuisine infused with Mediterranean twists as you savor special time with loved ones here. In this beautiful baby shower venue, you and your guests can sit comfortably on white leather banquettes and soft brown couches. Host a distinct celebration in Santuari, a restaurant imbued with Moroccan influences. Here are some amazing baby shower venues in Los Angeles: Santuari, 6711 Forest Lawn Dr 40 Adorable Baby Shower Zoom Backgrounds. 10 Most Popular Baby Shower Entertainment Ideas.From lively Italian restaurants to contemporary-chic outdoor settings, you’re sure to find the perfect venue that aligns with your unique vision. The vibrant city offers a wealth of stunning spots that are ideal for parents-to-be from all backgrounds. Are you searching for the perfect place to celebrate your bundle of joy? Then look no further than these beautiful baby shower venues in Los Angeles! Beachside soirées, garden parties, and bistro afternoons are just a few of the ways you can host your baby shower in Los Angeles. This feature grants you unlimited access to the game’s powerful special abilities, such as the ability to freeze, burn, or explode bloons with incredible force. Unleash devastating special abilities without any limitations using our Bloons TD 6 hack. It empowers you to efficiently respond to challenging waves of bloons by rapidly enhancing your defenses. This feature eliminates the need to wait and grind for upgrades, allowing you to quickly reach the highest level and maximize the effectiveness of your towers. Instant Tower Upgradesįrustrated by the slow progression of upgrading your towers? 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Bloons TD 6 Hack Features: Unlimited Money and XP Genetic deletion of the taurine transporter (TauT) in mice reduces taurine concentrations in plasma and tissues, including the brain. Both TauT and GAT-2 are also able to efficiently carry hypotaurine. The blood-brain barrier also expresses the GABA transporter SLC6A13, known as GAT-2, which is capable of carrying taurine across membranes. Taurine uptake or efflux at both luminal and albumen membranes has been proposed to be mediated by SLC6A6 transporter, also called TauT. The passive diffusion of taurine across the blood-brain barrier is negligible. Taurine, as well as hypotaurine, β-alanine, and other β-amino acids, are taken up through the blood–brain barrier into the brain by a high-affinity, low-capacity Na +- and Cl −-dependent transport system. In most mammals, taurine is mainly synthetized in the liver and then actively transported through the blood-brain barrier into the brain parenchyma. Taurine in the brain results from its transport from the periphery (believed to be the main source) and local de novo synthesis. This is clear evidence advocating for the importance of taurine. Enzymes that synthetize taurine show low activity in cats, dogs, and foxes, which develop pathologies when fed a taurine-deficient diet, namely, cardiomyopathy and myocardial dysfunction, retinal degeneration, neurological abnormalities, weakened immune response, pregnancy and fetal development complications, as well as gastrointestinal problems (see and references therein). In addition, brain taurine is known as an osmoregulator and neuromodulator and is involved in numerous processes, such as the modulation of neuronal excitability, the cerebral control of the cardiorespiratory system, appetite regulation, resistance to hypoxia, osmoregulation, and anti-oxidation. Namely, taurine treatments have been shown to protect tissues and cells against oxidative stress (e.g., ), mitochondrial stress (e.g., ), or inflammation (e.g., ). The neuroprotective effects of taurine have received considerable attention, and there is a plethora of publications showing the ability of exogenously added taurine to prevent toxicity in neurons or astrocytes in vitro, as well as in animal models of neurological disorders (reviewed by Jakaria et al. Taurine supplementation has been suggested to have beneficial effects on a number of disorders, for example, hypertension, congestive heart failure, ischemia–reperfusion myocardial injury, intracerebral hemorrhage, pulmonary fibrosis, obesity-induced low-grade inflammation. Together with glycine, taurine is well known for bile acid amidation, producing bile salts for excretion. Taurine is obtained from the diet or results from de novo synthesis through catabolism of the amino acid cysteine ( Figure 1). Taurine, or 2-aminoethanesulfonic acid, was first isolated from ox bile in 1827, by Friedrich Tiedemann and Leopold Gmelin. We conclude that further research is needed for understanding taurine homeostasis in metabolic disorders with an impact on brain function. The present article provides an overview of brain taurine homeostasis and reviews the mechanisms by which taurine can afford neuroprotection in individuals with obesity and diabetes. Given the possible cytoprotective actions of taurine, such cerebral accumulation of taurine might constitute a compensatory mechanism that attempts to prevent neurodegeneration. On the other hand, models of insulin-dependent diabetes, insulin resistance, and diet-induced obesity display taurine accumulation in the hippocampus. Models of neurodegenerative disorders show reduced brain taurine concentrations. Alterations to taurine homeostasis can impact a number of biological processes, such as osmolarity control, calcium homeostasis, and inhibitory neurotransmission, and have been reported in both metabolic and neurodegenerative disorders. Obesity, type 2 diabetes, and their associated comorbidities impact brain metabolism and function and constitute risk factors for cognitive impairment. |
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